HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 4-{4-[5-(4-Fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}tetrahydropyran-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride | HCID 22646672 | — |
| Reactant | 4-[4-(4-Bromophenyl)piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acid | HCID 22646679 | — |
| Reactant | 4-Chlorosulfonyl-methyltetrahydropyran-4-carboxylic acid methyl ester | HCID 86590244 | — |
| Product | 4-{4-[5-(4-Fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}tetrahydropyran-4-carboxylic acid | HCID 22646723 | 81% |
Reaction Steps
Prepared according to the method for the preparation of 4-[4-(4-bromophenyl)-piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acid, from 5-(4-fluoro-phenyl)-2-piperazin-1-ylpyrimidine dihydrochloride (0.27 g), and 4-chlorosulfonyl-methyltetrahydropyran-4-carboxylic acid methyl ester (0.25 g), to yield the title compound as white solid (0.31 g, 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06787536B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-3a93c315df8c4bb7a7bd2ba4f78bb264 |
| Source note | uspto-grants-2004_09 |