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HRID1005857

反应详情

EQUATION

反应方程式

HRID 1005857 的结构方程式

REACTANTS

反应物

3
结构：OB(O)c1ccc(Cl)cc1
HCID74299

Benzeneboronic acid, p-chloro-

C6H6BClO2

结构：CC(C)(C)OC(=O)N1CCN(c2ccc(Br)cn2)CC1
HCID11244775

Tert-butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate

C14H20BrN3O2

结构：CC(C)(C)OC(=O)N1CCN(c2ncc(-c3ccc(F)cc3)cn2)CC1
HCID69850026

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCN(c2ccc(-c3ccc(Cl)cc3)cn2)CC1
HCID69895399

未命名化合物

收率 99.1%

PROCEDURE

实验过程

Prepared according to the method for the preparation of 4-[5-(4-fluorophenyl)-pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester, from 4-(5-bromo-pyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (0.536 g) and 4-chlorophenylboronic acid (0.269 g), to yield the title compound as a beige solid (0.580 g, 99%).

WORKUP

后处理

  1. customPrepared