HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenylboronic acid → 4-[5-(4-Chlorophenyl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Reactant | 4-Boc-1-(5-bromo-2-pyridyl)piperazine | HCID 11244775 | — |
| Reactant | Tert-butyl 4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylate | HCID 69850026 | — |
| Product | 4-[5-(4-Chlorophenyl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester | HCID 69895399 | 99.1% |
Reaction Steps
Prepared according to the method for the preparation of 4-[5-(4-fluorophenyl)-pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester, from 4-(5-bromo-pyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (0.536 g) and 4-chlorophenylboronic acid (0.269 g), to yield the title compound as a beige solid (0.580 g, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06787536B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-eb9bcb8711d84298889e3411a78541dc |
| Source note | uspto-grants-2004_09 |