4-Fluorophenylboronic acid → 4-[5-(4-Fluorophenyl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester

HRID 1005861Notes

Reaction equation

HRID 1005861 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)=[CH:16]N=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:27](OC(N1CCN(C2C=CC(Br)=CN=2)CC1)=O)(C)(C)C.FC1C=CC(B(O)O)=CC=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:27]=[CH:16][C:17]([C:20]3[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=3)=[CH:18][N:19]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 2856454-Fluorophenylboronic acidHCID 112447754-Boc-1-(5-bromo-2-pyridyl)piperazineHCID 69850026Tert-butyl 4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylate

Product 1

HCID 698957074-[5-(4-Fluorophenyl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl esterYield 99%

Procedure

Prepared according to the method for the preparation of 4-[5-(4-fluorophenyl)-pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester, from 4-(5-bromo-pyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (0.151 g) and 4-fluorophenylboronic acid (0.068 g), to give the title compound as a white solid (0.155 g, 99%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a7490dc505fe45afa49d8b9e3f7fd688
Source dataset
uspto-grants-2004_09
Patent number
US06787536B2

Reaction notes

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