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4-Fluorophenylboronic acid → 4-[5-(4-Fluorophenyl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorophenylboronic acid | HCID 285645 | — |
| 反応物 | 4-Boc-1-(5-bromo-2-pyridyl)piperazine | HCID 11244775 | — |
| 反応物 | Tert-butyl 4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylate | HCID 69850026 | — |
| 生成物 | 4-[5-(4-Fluorophenyl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester | HCID 69895707 | 99% |
反応手順
Prepared according to the method for the preparation of 4-[5-(4-fluorophenyl)-pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester, from 4-(5-bromo-pyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (0.151 g) and 4-fluorophenylboronic acid (0.068 g), to give the title compound as a white solid (0.155 g, 99%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06787536B2 |
| 出典データセット | uspto-grants-2004_09 |
| ORD ID | ord-a7490dc505fe45afa49d8b9e3f7fd688 |
| 出典メモ | uspto-grants-2004_09 |