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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1005865Generated: October 27, 2026

Piperidin-4-ol → Tert-butyl 4-hydroxypiperidine-1-carboxylate

https://huagongshe.com/reaction/1005865

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperidin-4-olHCID 79341—
ReactantTert-butyl 4-(4-bromophenyl)piperazine-1-carboxylateHCID 11824027—
ProductTert-butyl 4-hydroxypiperidine-1-carboxylateHCID 643502—

Reaction Steps

Prepared according to the method for the preparation of 4-(4-bromophenyl)-piperazine-1-carboxylic acid tert-butyl ester, from 4-hydroxypiperidine (18.4 g), to give the title compound as a light orange oil that crystalised from hexane (25.6 g, 71%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06787536B2
Source datasetuspto-grants-2004_09
ORD IDord-ff6d79509d304982a4c2d178d5f4a692
Source noteuspto-grants-2004_09