Piperidin-4-ol → Tert-butyl 4-hydroxypiperidine-1-carboxylate

HRID 1005865Notes

Reaction equation

HRID 1005865 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12]N(C2C=CC(Br)=CC=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH:21][CH:22]1CCNCC1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:22]([OH:21])[CH2:12][CH2:13]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 11824027Tert-butyl 4-(4-bromophenyl)piperazine-1-carboxylate

Product 1

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Procedure

Prepared according to the method for the preparation of 4-(4-bromophenyl)-piperazine-1-carboxylic acid tert-butyl ester, from 4-hydroxypiperidine (18.4 g), to give the title compound as a light orange oil that crystalised from hexane (25.6 g, 71%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ff6d79509d304982a4c2d178d5f4a692
Source dataset
uspto-grants-2004_09
Patent number
US06787536B2

Reaction notes

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