Methyl cyclohexanecarboxylate → Methyl 1-(iodomethyl)cyclohexanecarboxylate

HRID 1005884Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1([CH2:11][I:12])[CH2:10][CH2:9]O[CH2:7][CH2:6]1)=[O:4].[CH3:13]OC(C1CCCCC1)=O>>[CH3:1][O:2][C:3]([C:5]1([CH2:11][I:12])[CH2:10][CH2:9][CH2:13][CH2:7][CH2:6]1)=[O:4]

Participants

Reactant 2

HCID 20748Methyl cyclohexanecarboxylate

HCID 227197884-Iodomethyl-tetrahydro-pyran-4-carboxylic acid methyl ester

Product 1

HCID 58947958Methyl 1-(iodomethyl)cyclohexanecarboxylateYield 100%

Procedure

Prepared according to the method for the preparation of 4-iodomethyltetrahydropyran-4-carboxylic acid methyl ester, from cyclohexane-carboxylic acid methyl ester (10 ml), to give the title compound as a brown gum (20 g, 100%).

Workup

customPrepared

Sources & evidence

ORD record: ord-2efadd1307e64ed6a9b3aebd237fa48d
Source dataset: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06787536B2

Reaction notes

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