4-(R)-benzyl-3-(2-(R)-chlorosulfonylmethyl-3 methylbutyryl)oxazolidin-2-one → 1-Chlorosulfonylmethylcyclohexanecarboxylic acid methyl ester

HRID 1005886Notes

Reaction equation

HRID 1005886 reaction equation
C([C@@H]1COC(=O)N1C(=O)[C@H]([CH2:19][S:20]([Cl:23])(=[O:22])=[O:21])C(C)C)C1C=CC=CC=1.[CH3:25][O:26][C:27]([C:29]1(SC(=O)C)[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]1C)=[O:28]>>[CH3:25][O:26][C:27]([C:29]1([CH2:19][S:20]([Cl:23])(=[O:22])=[O:21])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]1)=[O:28]

Participants

3

Reactant 2

HCID 228882844-(R)-benzyl-3-(2-(R)-chlorosulfonylmethyl-3 methylbutyryl)oxazolidin-2-oneHCID 865902451-Acetylsulfanyl-methylcyclohexanecarboxylic acid methyl ester

Product 1

HCID 589479561-Chlorosulfonylmethylcyclohexanecarboxylic acid methyl esterYield 96%

Procedure

Prepared according to the method for the preparation of 4-(R)-benzyl-3-(2-(R)-chlorosulfonylmethyl-3-methyl butyryl)oxazolidin-2-one, from 1-acetylsulfanyl-methylcyclohexanecarboxylic acid methyl ester (20 g), to provide the title compound as a red oil (14 g, 96%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-13153a13a3aa4509aa6323659d94fb9d
Source dataset
uspto-grants-2004_09
Patent number
US06787536B2

Reaction notes

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