2-[4-(4-furan-2-yl-phenyl)piperazine-1-sulfonylmethyl]-N-hydroxy-3-methylbutyramide → 2-[4-(4-Pyridin-3-yl-phenyl)piperazine-1-sulfonylmethyl]-N-hydroxy-3-methylbutyramide

HRID 1005896Notes

Reaction equation

HRID 1005896 reaction equation
O1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][N:15]([S:18]([CH2:21][CH:22]([CH:27]([CH3:29])[CH3:28])[C:23]([NH:25][OH:26])=[O:24])(=[O:20])=[O:19])[CH2:14][CH2:13]2)=[CH:8][CH:7]=1.CC(C)C(CS([N:40]1CCN(C2C=CC(C3C=NC=CC=3)=CC=2)C[CH2:41]1)(=O)=O)C(O)=O>>[N:40]1[CH:5]=[CH:4][CH:3]=[C:2]([C:6]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:17][CH2:16][N:15]([S:18]([CH2:21][CH:22]([CH:27]([CH3:29])[CH3:28])[C:23]([NH:25][OH:26])=[O:24])(=[O:20])=[O:19])[CH2:14][CH2:13]3)=[CH:8][CH:7]=2)[CH:41]=1

Participants

3

Reactant 2

HCID 99319692-[4-(4-furan-2-yl-phenyl)piperazine-1-sulfonylmethyl]-N-hydroxy-3-methylbutyramideHCID 226467343-Methyl-2-[4-(4-pyridin-3-yl-phenyl)piperazine-1-sulfonylmethyl]butyric acid

Product 1

HCID 101376802-[4-(4-Pyridin-3-yl-phenyl)piperazine-1-sulfonylmethyl]-N-hydroxy-3-methylbutyramideYield 76%

Procedure

Prepared according to the method for the preparation of 2-[4-(4-furan-2-yl-phenyl)piperazine-1-sulfonylmethyl]-N-hydroxy-3-methylbutyramide, from 3-methyl-2-[4-(4-pyridin-3-yl-phenyl)piperazine-1-sulfonylmethyl]butyric acid (0.075 g), to yield the title compound as a white solid (0.059 g, 76%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3a66d01aab1f4ddb8590e08f43608c16
Source dataset
uspto-grants-2004_09
Patent number
US06787536B2

Reaction notes

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