反应详情

0.67 g of the compound obtained in Example 3b and 0.37 g of 5-chloro-2-mercaptobenzimidazole were refluxed for 5 hours in 15 ml of acetonitrile containing 0.25 g of triethylamine. The reaction mixture was cooled to room temperature, then added with water and extracted with ethyl acetate. The extract was dried over sodium sulfate and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane) to obtain 0.25 g of the title compound (yield: 42%).

1. extractionextracted with ethyl acetate
2. dry with materialThe extract was dried over sodium sulfate
3. customthe solvent was evaporated under reduced pressure
4. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane)