2-Chlorobenzothiazole → HCID 22675410, compound

HRID 1005965Notes

Reaction equation

HRID 1005965 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][S:7][C:8]1[NH:9][C:10]2[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=2[N:12]=1.Cl[C:18]1[S:19][C:20]2[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=2[N:22]=1>C(O)(C)C>[S:19]1[C:20]2[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=2[N:22]=[C:18]1[NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][S:7][C:8]1[NH:12][C:11]2[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=2[N:9]=1

Participants

4

Reactant 2

HCID 119872-ChlorobenzothiazoleHCID 22675462HCID 22675462, compound

Product 1

HCID 22675410HCID 22675410, compoundYield 43.3%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.6 g of the compound obtained in Example 17c and 0.34 g of 2-chloro-benzothiazole were refluxed for 23 hours in 15 ml of isopropanol. The reaction mixture was cooled to room temperature, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane) to obtain 0.32 g of the title compound (yield: 43%).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane)

Sources & evidence

ORD record
ord-95aa6a26bb554fb2a6990aaa0061d2b3
Source dataset
uspto-grants-2004_09
Patent number
US06787561B1

Reaction notes

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