2-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropanoyl chloride → HCID 10166611, compound

HRID 1005987Notes

Reaction equation

HRID 1005987 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[O:4][C:5]1[C:10]([NH:11][CH3:12])=[CH:9][N:8]=[C:7]([S:13][CH3:14])[N:6]=1.[F:19][C:20]([F:38])([F:37])[C:21]1[CH:22]=[C:23]([C:31]([CH3:36])([CH3:35])[C:32](Cl)=[O:33])[CH:24]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:26]=1>>[F:29][C:27]([F:28])([F:30])[C:25]1[CH:24]=[C:23]([C:31]([CH3:35])([CH3:36])[C:32]([N:11]([C:10]2[C:5]([O:4][C:3]3[CH:15]=[CH:16][CH:17]=[CH:18][C:2]=3[Cl:1])=[N:6][C:7]([S:13][CH3:14])=[N:8][CH:9]=2)[CH3:12])=[O:33])[CH:22]=[C:21]([C:20]([F:19])([F:37])[F:38])[CH:26]=1

Participants

3

Reactant 2

HCID 112671412-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropanoyl chlorideHCID 22674327HCID 22674327, compound

Product 1

HCID 10166611HCID 10166611, compound

Procedure

The resulting [4-(2-chloro-phenoxy)-2-methylsulfanyl-pyrimidin-5-yl]-methyl-amine was treated with 2-(3,5-bis-trifluormethyl-phenyl)-2-methyl-propionyl chloride as described in Example 43e) to give 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-chloro-phenoxy)-2-methylsulfanyl-pyrimidin-5-yl]-N-methyl-isobutyramide as a white foam, MS (ISP): 564.2 (M+H)+.

Sources & evidence

ORD record
ord-5675ed36de37463e8f6a262d151b8f99
Source dataset
uspto-grants-2004_09
Patent number
US06787539B2

Reaction notes

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