反应详情

A mixture of 2-bromomethyl-4-bromophenyl benzyl ether (0.28 moles) and NaCN (16 g) in DMF (200 ml) was stirred at ambient temperature for 16 hours, then heated at 100° C. for 5 hours. A further 2 g of NaCN was added and the reaction heated for 5 hours at 100° C. The mixture was diluted with water (200 ml) and stirred (1 hour). The resulting solid was filtered off and recrystallised from methanol to give 4-bromo-2-cyanomethylphenyl benzyl ether (48 g) mpt. 75-76° C.

1. temperatureheated at 100° C. for 5 hours
2. temperaturethe reaction heated for 5 hours at 100° C
3. stirringstirred (1 hour)
4. filtrationThe resulting solid was filtered off
5. customrecrystallised from methanol