関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 5-Aminoacenaphthene | HCID 62547 | — |
| 反応物 | 1-(Bromomethyl)-4-(1,1-dimethylethyl)benzene | HCID 87836 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-(5-acenaphthyl)-4-tert-butylbenzylamine | HCID 15480727 | — |
反応手順
A mixture of 5-acenaphthylamine (1.0 g, 6 mmol) and triethylamine (0.76 g, 7.5 mmol) in toluene (50 mL) was stirred at 4° C., and 4-tert-butylbenzyl-bromide (1.36 g, 6 mmol) was added in slowly. The reaction mixture was stirred at 23° C. for 15 hours and precipitates formed. The precipitates (triethylamine.HBr) were filtered out; the filtrate was concentrated to dryness. Then the crude reaction mixture was purified by column chromatography (SiO2, hexane/CH2Cl2=5/1). N-(5-acenaphthyl)-4-tert-butylbenzylamine (1.67 g, an oil) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06787569B1 |
|---|
| 出典データセット | uspto-grants-2004_09 |
|---|
| ORD ID | ord-3bf4d2f04cad4df289538929237976eb |
|---|
| 出典メモ | uspto-grants-2004_09 |
|---|
