反应详情

温度

4 °C

A mixture of 5-acenaphthylamine (1.0 g, 6 mmol) and triethylamine (0.76 g, 7.5 mmol) in toluene (50 mL) was stirred at 4° C., and 4-tert-butylbenzyl-bromide (1.36 g, 6 mmol) was added in slowly. The reaction mixture was stirred at 23° C. for 15 hours and precipitates formed. The precipitates (triethylamine.HBr) were filtered out; the filtrate was concentrated to dryness. Then the crude reaction mixture was purified by column chromatography (SiO2, hexane/CH2Cl2=5/1). N-(5-acenaphthyl)-4-tert-butylbenzylamine (1.67 g, an oil) was obtained.

1. stirringThe reaction mixture was stirred at 23° C. for 15 hours
2. customprecipitates
3. customformed
4. customThe precipitates (triethylamine.HBr)
5. filtrationwere filtered out
6. concentrationthe filtrate was concentrated to dryness
7. customThen the crude reaction mixture
8. customwas purified by column chromatography (SiO2, hexane/CH2Cl2=5/1)