Hydrochloric Acid → HCID 22676849, compound

Participants

Reaction Steps

To a solution of 78.0 mg (0.1 mmol) of 1,3-bis[4-[4-(4-acetyl-3,5-dimethoxyphenyl) benzoyl]-1-piperazinyl]propane in chloroform (3.0 mL) was added 0.063 mL (0.25 mmol) of a 4.0 mol/L ethyl acetate solution of hydrogen chloride, and the mixture was concentrated under reduced pressure. The residue was crystallized from chloroform-diethyl ether to afford 40.0 mg of 1,3-bis[4-[4-(4-acetyl-3,5-dimethoxyphenyl)benzoyl]-1-piperazinyl]propane dihydrochloride as a pale brown crystalline powder (yield: 47%). mp: 240.0° C. (decomposed)

Provenance & Evidence