Hydrochloric Acid → HCID 22676849, compound

HRID 1006240Notes

Reaction equation

HRID 1006240 reaction equation
[C:1]([C:4]1[C:9]([O:10][CH3:11])=[CH:8][C:7]([C:12]2[CH:55]=[CH:54][C:15]([C:16]([N:18]3[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][N:27]4[CH2:32][CH2:31][N:30]([C:33](=[O:53])[C:34]5[CH:39]=[CH:38][C:37]([C:40]6[CH:45]=[C:44]([O:46][CH3:47])[C:43]([C:48](=[O:50])[CH3:49])=[C:42]([O:51][CH3:52])[CH:41]=6)=[CH:36][CH:35]=5)[CH2:29][CH2:28]4)[CH2:20][CH2:19]3)=[O:17])=[CH:14][CH:13]=2)=[CH:6][C:5]=1[O:56][CH3:57])(=[O:3])[CH3:2].C(OCC)(=O)C.[ClH:64]>C(Cl)(Cl)Cl>[ClH:64].[ClH:64].[C:48]([C:43]1[C:44]([O:46][CH3:47])=[CH:45][C:40]([C:37]2[CH:36]=[CH:35][C:34]([C:33]([N:30]3[CH2:31][CH2:32][N:27]([CH2:26][CH2:25][CH2:24][N:21]4[CH2:22][CH2:23][N:18]([C:16](=[O:17])[C:15]5[CH:14]=[CH:13][C:12]([C:7]6[CH:8]=[C:9]([O:10][CH3:11])[C:4]([C:1](=[O:3])[CH3:2])=[C:5]([O:56][CH3:57])[CH:6]=6)=[CH:55][CH:54]=5)[CH2:19][CH2:20]4)[CH2:28][CH2:29]3)=[O:53])=[CH:39][CH:38]=2)=[CH:41][C:42]=1[O:51][CH3:52])(=[O:50])[CH3:49]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 10485544HCID 10485544, compound

Product 1

HCID 22676849HCID 22676849, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 78.0 mg (0.1 mmol) of 1,3-bis[4-[4-(4-acetyl-3,5-dimethoxyphenyl) benzoyl]-1-piperazinyl]propane in chloroform (3.0 mL) was added 0.063 mL (0.25 mmol) of a 4.0 mol/L ethyl acetate solution of hydrogen chloride, and the mixture was concentrated under reduced pressure. The residue was crystallized from chloroform-diethyl ether to afford 40.0 mg of 1,3-bis[4-[4-(4-acetyl-3,5-dimethoxyphenyl)benzoyl]-1-piperazinyl]propane dihydrochloride as a pale brown crystalline powder (yield: 47%). mp: 240.0° C. (decomposed)

Workup

  1. concentrationthe mixture was concentrated under reduced pressure
  2. customThe residue was crystallized from chloroform-diethyl ether

Sources & evidence

ORD record
ord-3f9e465f966b43b0aab15781e452fb81
Source dataset
uspto-grants-2004_09
Patent number
US06787653B2

Reaction notes

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