Hydrochloric Acid → HCID 69818888, compound

HRID 1006362Notes

Reaction equation

HRID 1006362 reaction equation
[CH:1]([C@H:14]1[N:23]2[C@@H:18]([CH2:19][O:20][CH2:21][CH2:22]2)[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:31]>O1CCOCC1>[ClH:31].[ClH:31].[CH:1]([C@H:14]1[N:23]2[C@@H:18]([CH2:19][O:20][CH2:21][CH2:22]2)[CH2:17][NH:16][CH2:15]1)([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69818680HCID 69818680, compound

Product 1

HCID 69818888HCID 69818888, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(6R,9aR)-6-Benzhydryl-8-(tert-butoxycarbonyl)octahydropyrazino[2,1-c][1,4]oxazine was treated with 4N hydrogen chloride in 1,4-dioxane to give (6R,9aR)-octahydro-6-benzhydrylpyrazino[2,1-c][1,4]oxazine dihydrochloride as a yellowish powder. (6R,9aR)-6-Benzhydryl-8-[2-methoxy-5-[5-(trifluoromethyl)-1H-tetrazol-1-yl]benzyl]octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride was obtained from (6R,9aR)-6-benzhydrylhexahydropyrazino[2,1-c][1,4]oxazine dihydrochloride according to a similar manner to that of Example 2.

Sources & evidence

ORD record
ord-34d64039efc0405d801bf968ff1e01c1
Source dataset
uspto-grants-2004_09
Patent number
US06787543B2

Reaction notes

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