HCID 69893569, compound → HCID 12132986, compound

HRID 1006430Notes

Reaction equation

HRID 1006430 reaction equation
[CH2:1]([N:3]([CH2:27][CH3:28])[C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=2)=[CH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:8][CH:7]=1)=[O:5])[CH3:2]>CO.[Pd]>[CH2:27]([N:3]([CH2:1][CH3:2])[C:4]([C:6]1[CH:7]=[CH:8][C:9]([CH:12]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=2)[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:10][CH:11]=1)=[O:5])[CH3:28]

Participants

4

Reactant 1

HCID 69893569HCID 69893569, compound

Product 1

HCID 12132986HCID 12132986, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Ethyl 3-(4-diethylcarbamoylphenyl)-3-(3-methoxyphenyl)acrylate (308 mg) synthesized by the method described in WO97/10230 was dissolved in methanol (6 ml), added with 10% palladium/carbon (60 mg) and stirred at room temperature for 22 hours under a hydrogen gas atmosphere. Insoluble solids were removed by filtration, and then the solvent was evaporated under reduced pressure to obtain 275 mg of the title compound. Yield: 89%.

Workup

  1. customInsoluble solids were removed by filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-395d2296bfbb4f1bab1ff95aa5205c9d
Source dataset
uspto-grants-2004_09
Patent number
US06790854B2

Reaction notes

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