Hydrogen Bromide → HCID 69892287, compound

HRID 1006443Notes

Reaction equation

HRID 1006443 reaction equation
[CH:1]1([C:4]([C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:26])[N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])=[CH:16][CH:15]=2)([C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[CH:7]=2)O)[CH2:3][CH2:2]1.[BrH:27].O>C(O)(=O)C>[Br:27][CH2:3][CH2:2][CH:1]=[C:4]([C:14]1[CH:19]=[CH:18][C:17]([C:20](=[O:26])[N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])=[CH:16][CH:15]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[CH:7]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 962WaterHCID 22671451HCID 22671451, compound

Product 1

HCID 69892287HCID 69892287, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1-Cyclopropyl-1-(4-diethylcarbamoylphenyl)-1-(3-methoxyphenyl)Methanol (90.9 mg) was dissolved in acetic acid (1.8 ml), added with 48% hydrobromic acid (1.8 ml) with ice cooling and stirred at room temperature for 1.5 hours. The reaction mixture was added with water (5 ml) and extracted twice with dichloromethane (5 ml). The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure to obtain 102 mg of the title compound. Yield: 95%.

Workup

  1. extractionextracted twice with dichloromethane (5 ml)
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-6a8d997edf1c46018018a17138423734
Source dataset
uspto-grants-2004_09
Patent number
US06790854B2

Reaction notes

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