tert-Butyl methyl ether → HCID 9922991, compound

HRID 1006447Notes

Reaction equation

HRID 1006447 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH3:7].[Br:8][CH2:9][C:10]([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)=[O:11].COC(C)(C)C>C(O)C>[Br-:8].[S:13]1[CH:14]=[CH:15][CH:16]=[C:12]1[C:10](=[O:11])[CH2:9][N+:3]1[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][CH:4]=1

Participants

5

Reactant 3

HCID 15413tert-Butyl methyl etherHCID 625104,5-DimethylthiazoleHCID 27763722-Bromo-1-(thiophen-2-yl)ethan-1-one

Product 1

HCID 9922991HCID 9922991, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4,5-dimethylthiazole (2.2 g, 19.4 mmol) and 2-bromoacetylthiophene (4 g, 19.4 mmol) in ethyl alcohol (20 mL) was refluxed for 3 hours. It was cooled to room temperature and t-butyl methyl ether (10 mL) was added. The reaction mixture was left at room temperature overnight with stirring. The white product separated and was filtered and dried. It was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.

Workup

  1. customThe white product separated
  2. filtrationwas filtered
  3. customdried
  4. customIt was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.

Sources & evidence

ORD record
ord-c705dd71e5d64b6d9bc0972dd55830ae
Source dataset
uspto-grants-2004_09
Patent number
US06790859B2

Reaction notes

Loading…