Sulfuric Acid → 7-bromo-2-(bromomethyl)-5-fluoro-4H-1,3-benzodioxine

HRID 100647Notes

Reaction equation

HRID 100647 reaction equation
[Br:12][CH2:13][CH:14]([O:15][CH3:16])[O:17][CH3:18].[Br:1][c:2]1[cH:3][c:4]([F:11])[c:5]([CH2:9][OH:10])[c:6]([OH:8])[cH:7]1.[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[S:19](=[O:20])(=[O:21])([OH:22])[OH:23]>>[Br:1][c:2]1[cH:3][c:4]([F:11])[c:5]2[c:6]([cH:7]1)[O:8][CH:14]([CH2:13][Br:12])[O:10][CH2:9]2

Participants

5

Reactant 4

HCID 1118Sulfuric AcidHCID 8028TetrahydrofuranHCID 816722-Bromo-1,1-dimethoxyethaneHCID 671557215-Bromo-3-fluoro-2-(hydroxymethyl)phenol

Product 1

HCID 671556997-bromo-2-(bromomethyl)-5-fluoro-4H-1,3-benzodioxine

Sources & evidence

ORD record
ord-eba7a0e119204262b20e6e0f291daf74
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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