Water → HCID 178508255, compound

HRID 1006485Notes

Reaction equation

HRID 1006485 reaction equation
[NH2:1][C:2]1[NH:7][C:6]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:5][C:4](=[O:16])[C:3]=1[S:17][C:18]#[N:19].O>CN(C)C=O>[NH2:19][C:18]1[S:17][C:3]2[C:4](=[O:16])[N:5]=[C:6]([S:8][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[NH:7][C:2]=2[N:1]=1

Participants

4

Reactant 2

HCID 962WaterHCID 178514143HCID 178514143, compound

Product 1

HCID 178508255HCID 178508255, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product of example 1 step a) (7.35 g) was heated at 120° C. in N,N-dimethylformamide (40 ml)/water (10 ml) for 10 hours. After cooling, the resulting solid was filtered off, washed with water, then ethyl acetate to give the subtitle compound.

Workup

  1. temperatureAfter cooling
  2. filtrationthe resulting solid was filtered off
  3. washwashed with water

Sources & evidence

ORD record
ord-1fcf2d2f7ea14ba5a404b32f6bee0f4a
Source dataset
uspto-grants-2004_09
Patent number
US06790850B1

Reaction notes

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