Sodium Hydroxide → HCID 69920491, compound

HRID 1006566Notes

Reaction equation

HRID 1006566 reaction equation
[CH:1]([N:4]([S:28]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)(=[O:30])=[O:29])[C:5]1[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][C:6]=1[O:7][CH2:8][C:9]1[CH:19]=[CH:18][C:12]([CH:13]=[CH:14][C:15]([OH:17])=[O:16])=[CH:11][CH:10]=1)([CH3:3])[CH3:2].[OH-].[Na+:38]>CO>[Na+:38].[CH:1]([N:4]([S:28]([C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)(=[O:29])=[O:30])[C:5]1[CH:23]=[CH:22][C:21]([C:24]([F:26])([F:25])[F:27])=[CH:20][C:6]=1[O:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([CH:13]=[CH:14][C:15]([O-:17])=[O:16])=[CH:18][CH:19]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69920246HCID 69920246, compound

Product 1

HCID 69920491HCID 69920491, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4-[2-(N-isopropyl-phenylsulfonylamino)-5-trifluoromethylphenoxymethyl]cinnamic acid (425 mg; prepared in Example 18(40).) in MeOH (5 ml), 2N NaOH (0.41 ml) was added. The mixture was stirred at room temperature. The mixture was distilled off azeotropically with benzene three times to give the title compound (430 mg) having the following physical data.

Workup

  1. distillationThe mixture was distilled off azeotropically with benzene three times

Sources & evidence

ORD record
ord-79d65e22f02940b788fc3d43885b4faf
Source dataset
uspto-grants-2004_09
Patent number
US06790866B2

Reaction notes

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