Methoxyacetic Acid → 2-Methoxymethyl-1-phenylmethyl-1H-imidazo[4,5-c]quinoline

HRID 1006632Notes

Reaction equation

HRID 1006632 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:20][O:21][CH2:22][C:23](O)=O>>[CH3:20][O:21][CH2:22][C:23]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]2[C:10]3[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=3[N:4]=[CH:3][C:2]=2[N:1]=1

Participants

3

Reactant 2

HCID 12251Methoxyacetic AcidHCID 15224414HCID 15224414, compound

Product 1

HCID 226726612-Methoxymethyl-1-phenylmethyl-1H-imidazo[4,5-c]quinoline

Procedure

Using the general method of Example 91, 3-amino-4-(phenylmethylamino)quinoline (4.0 g, 16 mmol) was reacted with methoxyacetic acid (3.7 mL) to provide 4.4 g of the desired product as a solid. The structure was confirmed by nuclear magnetic resonance spectroscopy.

Sources & evidence

ORD record
ord-7c4528c5ca9443899c24834f436c37bd
Source dataset
uspto-grants-2004_09
Patent number
US06790961B2

Reaction notes

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