4-Hydroxy-3-methoxybenzonitrile → 3,4-Dihydroxybenzonitrile

HRID 1006704Notes

Reaction equation

HRID 1006704 reaction equation
C([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[OH:12])[C:7]#[N:8])C.COC1C=C(C=CC=1O)C#N>>[OH:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[OH:12])[C:7]#[N:8]

Participants

3

Reactant 2

HCID 781354-Hydroxy-3-methoxybenzonitrileHCID 38006593-Ethoxy-4-hydroxybenzonitrile

Product 1

HCID 870653,4-DihydroxybenzonitrileYield 79%

Procedure

The preparation was carried out according to the process of Example 2a except that 3-ethoxy-4-hydroxybenzonitrile was used as the starting material instead of 3-methoxy-4-hydroxybenzonitrile. 3,4-Dihydroxybenzonitrile was obtained as a white solid with a yield of 79% and a purity of greater than 98% as indicated by HPLC analysis.

Sources & evidence

ORD record
ord-7450eadda5e644f0b7ccb99a85617cf5
Source dataset
uspto-grants-2004_09
Patent number
US06790977B2

Reaction notes

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