Hydrochloric Acid → HCID 22672711, compound

HRID 1006762Notes

Reaction equation

HRID 1006762 reaction equation
Cl.[CH2:2]([N:6]([CH3:24])[C:7](=[O:23])[C:8]#[C:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][SiH2]C(C)(C)C(C)C)[CH2:3][CH2:4][CH3:5]>>[CH2:2]([N:6]([CH3:24])[C:7](=[O:23])[C:8]#[C:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][OH:15])[CH2:3][CH2:4][CH3:5]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 123381142HCID 123381142, compound

Product 1

HCID 22672711HCID 22672711, compoundYield 69%

Procedure

1 ml of 2N hydrochloric acid was added to a solution of 1.9 g of the product of Step C and the mixture was maintained for one hour at ambient temperature, then extracted with ethyl acetate. The extracts were washed with water, dried and evaporated to dryness under reduced pressure. The 1.79 g of residue were chromatographed on silica (eluant: ethyl acetate) to obtain 870 mg of the expected product.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe extracts were washed with water
  3. customdried
  4. customevaporated to dryness under reduced pressure
  5. customThe 1.79 g of residue were chromatographed on silica (eluant: ethyl acetate)

Sources & evidence

ORD record
ord-b92de009a4444a828ef8c0984aa34f6c
Source dataset
uspto-grants-2004_09
Patent number
US06790971B1

Reaction notes

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