反应详情

温度

0 °C

6.88 g of triphenyl phosphine were added to a solution of 5.27 g of the product of Step B in 52 ml of methylene chloride and the mixture was cooled to 0° C. to +5° C. under a nitrogen atmosphere. 8.68 g of tetrabromo methane were added with stirring for one hour at 0° C. The reaction mixture was chromatographed on silica (eluant: cyclohexane-ethyl acetate 2-1) to obtain 6.2 g of the expected product.

1. temperaturethe mixture was cooled to 0° C. to +5° C. under a nitrogen atmosphere
2. customThe reaction mixture was chromatographed on silica (eluant: cyclohexane-ethyl acetate 2-1)