HCID 69431580, compound → HCID 69429829, compound

HRID 1006816Notes

Reaction equation

HRID 1006816 reaction equation
C[O:2][C:3](=[O:40])[C@@H:4]([O:9][CH2:10][C@@H:11]1[CH2:15][C@@H:14]([S:16][C:17]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:13][N:12]1[S:36]([CH3:39])(=[O:38])=[O:37])[CH2:5][CH:6]([CH3:8])[CH3:7]>CCO.C1COCC1>[CH3:39][S:36]([N:12]1[CH2:13][C@H:14]([S:16][C:17]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:15][C@H:11]1[CH2:10][O:9][C@@H:4]([CH2:5][CH:6]([CH3:8])[CH3:7])[C:3]([OH:40])=[O:2])(=[O:37])=[O:38]

Participants

3

Reactant 1

HCID 69431580HCID 69431580, compound

Product 1

HCID 69429829HCID 69429829, compound

Reagents, catalysts & solvents 1

HCID 21873804Tetrahydrofuran ethanolSolvent

Procedure

Hydrolysis in EtOH/THF (see General method for hydrolysis of an ester): (R)- or (S)-2-[(2S,4R)-1-methanesulfonyl-4-tritylsulfanyl-pyrrolidin-2-ylmethoxy]-4-methyl-pentanoic acid methyl ester gave (R)- or (S)-2-[(2S,4R)-1-methanesulfonyl-4-tritylsulfanyl-pyrrolidin-2-ylmethoxy]-4-methyl-pentanoic acid, MS: 568 (MH+); and (S)- or (R)-2-[(2S,4R)-1-methanesulfonyl-4-tritylsulfanyl-pyrrolidin-2-ylmethoxy]-4-methyl-pentanoic acid methyl ester gave (R)- or (S)-2-[(2S,4R)-1-Methanesulfonyl-4-tritylsulfanyl-pyrrolidin-2-ylmethoxy]-4-methyl-pentanoic acid, MS: 568 (MH+).

Sources & evidence

ORD record
ord-7622812425634fa9a986af724e29cc87
Source dataset
uspto-grants-2004_09
Patent number
US06790860B2

Reaction notes

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