反应详情

2-(2-Thienyl)ethanol (2.6 g) was dissolved in N,N-dimethylformamide (20 ml), followed by the addition of t-butyldimethylsilyl chloride (3.667 g) and imidazole (1.634 g) and the mixture was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and water. The resulting organic layer was washed with water, dried (over MgSO4) and evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane system), to give the title compound as a colorless oil (4.87 g, yield; 100%).

1. customThe reaction mixture was partitioned between ethyl acetate and water
2. washThe resulting organic layer was washed with water
3. dry with materialdried (over MgSO4)
4. customevaporated
5. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane system)