Phosphorus oxychloride → HCID 22502442, compound

HRID 1006907Notes

Reaction equation

HRID 1006907 reaction equation
[CH3:1][NH:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:5]=1[CH3:12].[F:14][C:15]([F:25])([F:24])[C:16]1[CH:23]=[CH:22][C:19](C#N)=[CH:18][CH:17]=1.P(Cl)(Cl)([Cl:28])=O>>[ClH:28].[ClH:28].[Cl:28][C:3]1[C:4]2[C:5](=[CH:6][C:7]([O:10][CH3:11])=[CH:8][CH:9]=2)[CH:12]=[C:1]([C:19]2[CH:22]=[CH:23][C:16]([C:15]([F:25])([F:24])[F:14])=[CH:17][CH:18]=2)[N:2]=1

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 67995Benzonitrile, 4-(trifluoromethyl)-HCID 22502967HCID 22502967, compound

Product 1

HCID 22502442HCID 22502442, compound

Procedure

6-Methoxy-3-(4-trifluoromethylphenyl)isoquinolin-1-one obtained by reacting n-methyl-4-methoxy-2-methylbenzamide (1.0 g) and 4-trifluoromethylbenzonitrile (0.96 g) according to Example 10-1 was reacted with phosphorus oxychloride (10 ml) according to Example 10-2, to give 1-chloro-6-methoxy-3-(4-trifluoromethylphenyl)isoquinoline dihydrochloride.

Sources & evidence

ORD record
ord-ced097abfdf94c9eab2afc91087b0291
Source dataset
uspto-grants-2004_09
Patent number
US06790844B2

Reaction notes

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