Methylamine → N,2-Dimethyl-3-pyridinecarboxamide

HRID 1006927Notes

Reaction equation

HRID 1006927 reaction equation
[CH3:1][C:2]1[N:12]=[CH:11][CH:10]=[CH:9][C:3]=1[C:4](OCC)=[O:5].[CH3:13][NH2:14]>CO>[CH3:1][C:2]1[N:12]=[CH:11][CH:10]=[CH:9][C:3]=1[C:4]([NH:14][CH3:13])=[O:5]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 74401Ethyl 2-methylnicotinate

Product 1

HCID 12833322N,2-Dimethyl-3-pyridinecarboxamideYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To ethyl 2-methylnicotinate (24.2 g) was added a solution of 40% methylamine in methanol (150 ml), which was then heated in a sealed tube at 50° C. overnight. The reaction mixture was evaporated, to give the title compound as a pale yellow solid (20.781 g, yield; 95%).

Workup

  1. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-5185a0c1e0ae4625a178ecb3812d55ed
Source dataset
uspto-grants-2004_09
Patent number
US06790844B2

Reaction notes

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