Dichloromethane → 4-(3,3-dimethylbut-1-ynyl)-N-(4-(7-methoxy-1,5-naphthyridin-4-yloxy)phenyl)phthalazin-1-amine

HRID 100706Notes

Reaction equation

HRID 100706 reaction equation
[CH3:32][C:33]([C:34]#[CH:35])([CH3:36])[CH3:37].[Cl:1][c:2]1[n:3][n:4][c:5]([NH:12][c:13]2[cH:14][cH:15][c:16]([O:19][c:20]3[cH:21][cH:22][n:23][c:24]4[cH:25][c:26]([O:30][CH3:31])[cH:27][n:28][c:29]34)[cH:17][cH:18]2)[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12.[Cl:38][CH2:39][Cl:40].[Cu:41][I:42]>>[c:2]1([C:35]#[C:34][C:33]([CH3:32])([CH3:36])[CH3:37])[n:3][n:4][c:5]([NH:12][c:13]2[cH:14][cH:15][c:16]([O:19][c:20]3[cH:21][cH:22][n:23][c:24]4[cH:25][c:26]([O:30][CH3:31])[cH:27][n:28][c:29]34)[cH:17][cH:18]2)[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 135123,3-Dimethyl-1-butyneHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 866286654-chloro-N-(4-(7-methoxy-1,5-naphthyridin-4-yloxy)phenyl)phthalazin-1-amine

Product 1

HCID 673166724-(3,3-dimethylbut-1-ynyl)-N-(4-(7-methoxy-1,5-naphthyridin-4-yloxy)phenyl)phthalazin-1-amine

Sources & evidence

ORD record
ord-49628f5df8754ab69b141370e433d14d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…