Ethyl formate → HCID 12010723, compound

HRID 1007068Notes

Reaction equation

HRID 1007068 reaction equation
[CH3:1][N:2]1[C:6]([O:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14][NH2:15])[N:9]=2)=[CH:5][C:4]([C:16]([F:19])([F:18])[F:17])=[N:3]1.[CH:20](OCC)=[O:21]>>[CH3:1][N:2]1[C:6]([O:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14][NH:15][CH:20]=[O:21])[N:9]=2)=[CH:5][C:4]([C:16]([F:19])([F:17])[F:18])=[N:3]1

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 11149948HCID 11149948, compound

Product 1

HCID 12010723HCID 12010723, compound

Procedure

0.100 g (0.368 mmol) of 2-(1-methyl-3-trifluoromethyl-pyrazol-5-yloxy)-6-(aminomethyl)-pyridine in 5 ml of ethyl formate was heated at reflux for 3 h. The solution was then filtered through a cartridge packed with 3 g of silica gel and this cartridge was rinsed out with ethyl acetate. The filtrate was concentrated.

Workup

  1. temperatureat reflux for 3 h
  2. filtrationThe solution was then filtered through a cartridge
  3. washthis cartridge was rinsed out with ethyl acetate
  4. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-8a0dfc95780b4ab584f9aeea98ac2f09
Source dataset
uspto-grants-2004_09
Patent number
US06794336B2

Reaction notes

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