Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| Reactant | 6-Chloropyridine-2-carbonitrile | HCID 118424 | — |
| Reactant | HCID 131724594 | HCID 131724594 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 12009738 | HCID 12009738 | — |
Reaction Steps
4.00 g (28.9 mmol) of 2-chloro-6-cyanopyridine were introduced together with 9.57 g (69.3 mmol) of potassium /carbonate in 20 ml of anhydrous DMF, and 5.62 g (34.6 mmol) of 3-hydroxybenzotrifluoride were added. After 10 h of stirring at 90° C., H2O was added and the mixture was subjected to repeated extraction with ethyl acetate. The organic phase was then washed twice with water, dried over MgSO4 and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06794336B2 |
|---|
| Source dataset | uspto-grants-2004_09 |
|---|
| ORD ID | ord-0aab4510ee654b268234b9fff614ef93 |
|---|
| Source note | uspto-grants-2004_09 |
|---|
