Water → HCID 12009738, compound

HRID 1007070Notes

Reaction equation

HRID 1007070 reaction equation
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]#[N:9])[N:3]=1.[K].C(=O)([O-])[O-].[OH:15][C:16]1[CH:17]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:19]=[CH:20][CH:21]=1.O>CN(C=O)C>[F:23][C:22]([F:24])([F:25])[C:18]1[CH:17]=[C:16]([O:15][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([C:8]#[N:9])[N:3]=2)[CH:21]=[CH:20][CH:19]=1

Participants

6

Reactant 4

HCID 962WaterHCID 73763-(Trifluoromethyl)phenolHCID 1184246-Chloropyridine-2-carbonitrileHCID 131724594HCID 131724594, compound

Product 1

HCID 12009738HCID 12009738, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

4.00 g (28.9 mmol) of 2-chloro-6-cyanopyridine were introduced together with 9.57 g (69.3 mmol) of potassium /carbonate in 20 ml of anhydrous DMF, and 5.62 g (34.6 mmol) of 3-hydroxybenzotrifluoride were added. After 10 h of stirring at 90° C., H2O was added and the mixture was subjected to repeated extraction with ethyl acetate. The organic phase was then washed twice with water, dried over MgSO4 and concentrated.

Workup

  1. additionwere added
  2. extractionextraction with ethyl acetate
  3. washThe organic phase was then washed twice with water
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-0aab4510ee654b268234b9fff614ef93
Source dataset
uspto-grants-2004_09
Patent number
US06794336B2

Reaction notes

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