Nitric Acid → HCID 21918841, compound

HRID 1007077Notes

Reaction equation

HRID 1007077 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([NH2:9])=[O:8].O1CCCC1.[N+:15]([O-:18])([OH:17])=[O:16]>C(#N)C>[N+:15]([O-:18])([OH:17])=[O:16].[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([NH2:9])=[O:8]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 1046PyrazinamideHCID 8028Tetrahydrofuran

Product 1

HCID 21918841HCID 21918841, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

The compound is prepared starting from a solution of Pyrazinamide (2 g, 16.24 mmoles) in a mixture of acetonitrile (30 ml)/tetrahydrofuran (30 ml), by adding a 65% nitric acid solution (1.2 ml) in acetonitrile (5 ml), following then the procedure described in Example 5. Pyrazinamide nitrate salt as amorphous solid is obtained. Yield 74%.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-8fdd104521dc49fbb406a98a97a290cf
Source dataset
uspto-grants-2004_09
Patent number
US06794372B2

Reaction notes

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