Nitric Acid → HCID 86588304, compound

HRID 1007079Notes

Reaction equation

HRID 1007079 reaction equation
[CH3:1][C:2]1[S:6][C:5]([S:7][CH2:8][C:9]2[CH2:26][S:25][C@@H:12]3[C@H:13]([NH:16][C:17]([CH2:19][N:20]4[N:24]=[N:23][N:22]=[CH:21]4)=[O:18])[C:14](=[O:15])[N:11]3[C:10]=2[C:27]([OH:29])=[O:28])=[N:4][N:3]=1.[N+:30]([O-:33])([OH:32])=[O:31]>CO.C(#N)C>[CH3:1][C:2]1[S:6][C:5]([S:7][CH2:8][C:9]2[CH2:26][S:25][C@@H:12]3[C@H:13]([NH:16][C:17]([CH2:19][N:20]4[N:24]=[N:23][N:22]=[CH:21]4)=[O:18])[C:14](=[O:15])[N:11]3[C:10]=2[C:27]([OH:29])=[O:28])=[N:4][N:3]=1.[N+:30]([O-:33])([O-:32])=[O:31]

Participants

5

Reactant 2

HCID 944Nitric AcidHCID 33255Cefazolin

Product 1

HCID 86588304HCID 86588304, compoundYield 60%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6342AcetonitrileSolvent

Procedure

The compound is prepared by adding to a Cefazolin solution (1.5 g, 3.3 mmoles) in methanol (50 ml) a 65% nitric acid solution (0.250 ml) in acetonitrile (5 ml) and following then the procedure reported in Example 5. Cefazolin nitrate as amorphous solid is obtained. Yield 60%.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-955def51e9aa40919ef80b0db6be4116
Source dataset
uspto-grants-2004_09
Patent number
US06794372B2

Reaction notes

Loading…