反应详情

2-Methylaniline (5.44 ml, 51 mmol) and 2-chloro-9,10-dimethoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one (5 g, 17 mmol) were suspended in propan-2-ol (400 ml) and heated at reflux, under nitrogen, for 24 h. After cooling to room temperature, the solution was concentrated in vacuo and the residue purified by flash column chromatography [dichloromethane/methanol (98:2-96:4)] to afford the title compound (6.2 g, quantitative yield) as a yellow/orange solid.

1. temperatureheated
2. temperatureat reflux, under nitrogen, for 24 h
3. concentrationthe solution was concentrated in vacuo
4. customthe residue purified by flash column chromatography [dichloromethane/methanol (98:2-96:4)]