Hydrochloric Acid → tert-butyl N-[[4-(8-cyclohexyl-2,8-diazaspiro[4.5]decane-2-carbonyl)phenyl]methyl]-N-(1H-imidazol-2-ylmethyl)carbamate

HRID 100717Notes

Reaction equation

HRID 100717 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH2:9][c:10]1[nH:11][cH:12][cH:13][n:14]1)[CH2:15][c:16]1[cH:17][cH:18][c:19]([C:20](=[O:21])[OH:22])[cH:23][cH:24]1.[CH:27]1([N:33]2[CH2:34][CH2:35][C:36]3([CH2:37][CH2:38][NH:39][CH2:40]3)[CH2:41][CH2:42]2)[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]1.[ClH:25].[ClH:26]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH2:9][c:10]1[nH:11][cH:12][cH:13][n:14]1)[CH2:15][c:16]1[cH:17][cH:18][c:19]([C:20](=[O:21])[N:39]2[CH2:38][CH2:37][C:36]3([CH2:35][CH2:34][N:33]([CH:27]4[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]4)[CH2:42][CH2:41]3)[CH2:40]2)[cH:23][cH:24]1

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 219736124-((((1H-imidazol-2-yl)methyl)(tert-butoxycarbonyl)amino)methyl)benzoic acidHCID 675006728-Cyclohexyl-2,8-diazaspiro[4.5]decane

Product 1

HCID 91111943tert-butyl N-[[4-(8-cyclohexyl-2,8-diazaspiro[4.5]decane-2-carbonyl)phenyl]methyl]-N-(1H-imidazol-2-ylmethyl)carbamate

Sources & evidence

ORD record
ord-53247402c4db49c89e66d4a2879e9b18
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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