P-Anisidine → 6-chloro-N-(4-methoxyphenyl)nicotinamide

HRID 1007187Notes

Reaction equation

HRID 1007187 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][N:3]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=1>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([NH:19][C:16]2[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][CH:15]=2)=[O:7])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 7732P-AnisidineHCID 27821656-Chloronicotinoyl Chloride

Product 1

HCID 14832696-chloro-N-(4-methoxyphenyl)nicotinamide

Procedure

The title compound was prepared from 6-chloronicotinoyl chloride and p-anisidine and was obtained as a white solid as described in Example 1. 1H NMR (CDCl3): 8.85 (d, J=2.1, 1H), 8.19-8.15 (m, 1H), 7.65 (s, 1H), 7.54-7.46 (m, 3H), 6.96-6.91 (m, 2H), 3.83 (s, 3H).

Workup

  1. customwas obtained as a white solid

Sources & evidence

ORD record
ord-68631edfda744542aab574b52c732962
Source dataset
uspto-grants-2004_09
Patent number
US06794397B2

Reaction notes

Loading…