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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1007187Generated: October 28, 2026

P-Anisidine → 6-chloro-N-(4-methoxyphenyl)nicotinamide

https://huagongshe.com/reaction/1007187

Reaction equation

Participants

RoleNameHCIDCharge
ReactantP-AnisidineHCID 7732—
Reactant6-Chloronicotinoyl ChlorideHCID 2782165—
Product6-chloro-N-(4-methoxyphenyl)nicotinamideHCID 1483269—

Reaction Steps

The title compound was prepared from 6-chloronicotinoyl chloride and p-anisidine and was obtained as a white solid as described in Example 1. 1H NMR (CDCl3): 8.85 (d, J=2.1, 1H), 8.19-8.15 (m, 1H), 7.65 (s, 1H), 7.54-7.46 (m, 3H), 6.96-6.91 (m, 2H), 3.83 (s, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06794397B2
Source datasetuspto-grants-2004_09
ORD IDord-68631edfda744542aab574b52c732962
Source noteuspto-grants-2004_09