2-Methyl-4-methoxyaniline → 6-Chloro-N-(4-methoxy-2-methyl-phenyl)-nicotinamide

HRID 1007195Notes

Reaction equation

HRID 1007195 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][N:3]=1.[CH3:11][O:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[C:15]([CH3:20])[CH:14]=1>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([NH:17][C:16]2[CH:18]=[CH:19][C:13]([O:12][CH3:11])=[CH:14][C:15]=2[CH3:20])=[O:7])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 76102-Methyl-4-methoxyanilineHCID 27821656-Chloronicotinoyl Chloride

Product 1

HCID 98568436-Chloro-N-(4-methoxy-2-methyl-phenyl)-nicotinamide

Procedure

The title compound was prepared from 6-chloronicotinoyl chloride and 4-methoxy-2-methylaniline and was obtained as a white solid as described in Example 1. 1H NMR (CDCl3): 8.88 (bs, 1H), 8.19 (d, J=7.2, 1H), 7.61-7.47 (m, 3H), 6.81-6.79 (m, 2H), 3.81 (s, 3H), 2.30 (s, 3H).

Workup

  1. customwas obtained as a white solid

Sources & evidence

ORD record
ord-0876b758cc204d87af352f6d1cbde6bf
Source dataset
uspto-grants-2004_09
Patent number
US06794397B2

Reaction notes

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