2-Amino-5-bromo-3-nitropyridine → 6-Chloro-N-(5-bromo-3-nitro-2-pyridyl)-3-pyridinecarboxamide

HRID 1007206Notes

Reaction equation

HRID 1007206 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][N:3]=1.[NH2:11][C:12]1[C:17]([N+:18]([O-:20])=[O:19])=[CH:16][C:15]([Br:21])=[CH:14][N:13]=1>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([NH:11][C:12]2[C:17]([N+:18]([O-:20])=[O:19])=[CH:16][C:15]([Br:21])=[CH:14][N:13]=2)=[O:7])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 1388782-Amino-5-bromo-3-nitropyridineHCID 27821656-Chloronicotinoyl Chloride

Product 1

HCID 226689346-Chloro-N-(5-bromo-3-nitro-2-pyridyl)-3-pyridinecarboxamide

Procedure

The title compound was prepared from 6-chloronicotinoyl chloride and 2-amino-5-bromo-3-nitropyridine as a light yellow solid as described in Example 1. 1H NMR (CDCl3): 10.56 (s, 1H), 9.00 (d, J=2.7, 1H), 8.82 (d, J=2.1, 1H), 8.69 (d, J=2.1, 1H), 8.27-8.23 (m, 1H), 7.53 (d, J=8.1, 1H).

Sources & evidence

ORD record
ord-9516a97397d44db1ae37d2826ef21a5c
Source dataset
uspto-grants-2004_09
Patent number
US06794397B2

Reaction notes

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