6-Chloronicotinoyl Chloride → 6-Chloro-N-(4,5-dimethoxy-2-nitrophenyl)-3-pyridinecarboxamide

HRID 1007222Notes

Reaction equation

HRID 1007222 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][N:3]=1.[CH3:11][O:12][C:13]1[C:19]([O:20][CH3:21])=[CH:18][C:16]([NH2:17])=[C:15]([N+:22]([O-:24])=[O:23])[CH:14]=1>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([NH:17][C:16]2[CH:18]=[C:19]([O:20][CH3:21])[C:13]([O:12][CH3:11])=[CH:14][C:15]=2[N+:22]([O-:24])=[O:23])=[O:7])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 27821656-Chloronicotinoyl ChlorideHCID 46531524,5-Dimethoxy-2-nitroaniline

Product 1

HCID 102908946-Chloro-N-(4,5-dimethoxy-2-nitrophenyl)-3-pyridinecarboxamide

Procedure

The title compound was prepared from 6-chloronicotinoyl chloride and 4,5-dimethoxy-2-nitroaniline as a yellow solid as described in Example 1. 1H NMR (CDCl3): 11.84 (s, 1H), 9.04 (d, J=1.8, 1H), 8.66 (s, 1H), 8.25-8.21 (m, 1H), 7.77 (s, 1H), 7.53 (d, J=8.7, 1H), 4.07 (s, 3H), 3.97 (s, 3H).

Sources & evidence

ORD record
ord-0a3f719bd6324958999e9d5e5ee60f32
Source dataset
uspto-grants-2004_09
Patent number
US06794397B2

Reaction notes

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