4-Ethoxy-2-nitroaniline → HCID 22668919, compound

HRID 1007226Notes

Reaction equation

HRID 1007226 reaction equation
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][N:4]=1)#[N:2].[CH2:12]([O:14][C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[C:17]([N+:22]([O-:24])=[O:23])[CH:16]=1)[CH3:13]>>[C:1]([C:3]1[N:4]=[CH:5][C:6]([C:7]([NH:19][C:18]2[CH:20]=[CH:21][C:15]([O:14][CH2:12][CH3:13])=[CH:16][C:17]=2[N+:22]([O-:24])=[O:23])=[O:9])=[CH:10][CH:11]=1)#[N:2]

Participants

3

Reactant 2

HCID 692294-Ethoxy-2-nitroanilineHCID 27611086-Cyanopyridine-3-carboxylic acid

Product 1

HCID 22668919HCID 22668919, compound

Procedure

The title compound was prepared from 6-cyanonicotinic acid and 4-ethoxy-2-nitroaniline as a yellow solid as described in Example 15. 1H NMR (CDCl3): 11.22 (s, 1H), 9.31-9.30 (m, 1H), 8.81 (d, J=9.3, 1H), 8.42-8.38 (m, 1H), 7.90-7.87 (m, 1H), 7.76 (d, J=3.0, 1H), 7.34-7.30 (m, 1H), 4.12 (q, J=6.9, 2H), 1.47 (t, J=6.9, 3H).

Sources & evidence

ORD record
ord-8ea62917ad664373bf45fdb6554f1fe8
Source dataset
uspto-grants-2004_09
Patent number
US06794397B2

Reaction notes

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