Sodium Iodide → HCID 22668889, compound

HRID 1007246Notes

Reaction equation

HRID 1007246 reaction equation
[F:1][CH:2]([F:23])[C:3]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:7]([CH2:13][CH:14]([CH3:16])[CH3:15])[C:6]([CH2:17]Cl)=[C:5]([C:19]([F:22])([F:21])[F:20])[N:4]=1.[I-:24].[Na+]>CC(C)=O>[F:1][CH:2]([F:23])[C:3]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:7]([CH2:13][CH:14]([CH3:16])[CH3:15])[C:6]([CH2:17][I:24])=[C:5]([C:19]([F:22])([F:21])[F:20])[N:4]=1

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 22668817Methyl 2-(difluoromethyl)-5-(chloromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate

Product 1

HCID 22668889HCID 22668889, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Reaction of methyl 2-(difluoromethyl)-5-(chloromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate (U.S. Pat. No. 5,169,432 example 3) with sodium iodide in refluxing acetone according to the procedure known to those in the art yielded the product.

Workup

  1. customyielded the product

Sources & evidence

ORD record
ord-aadfa933016a4518ae723b74864e7832
Source dataset
uspto-grants-2004_09
Patent number
US06794396B2

Reaction notes

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