Pyrrole-2-carboxaldehyde → HCID 136360280, compound

HRID 1007260Notes

Reaction equation

HRID 1007260 reaction equation
[CH:1]12[CH2:7][CH:4]([CH:5]=[CH:6]1)[CH2:3][CH:2]2[NH:8][C:9]([NH:11][NH2:12])=[S:10].[NH:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[CH:18]=O>>[CH:1]12[CH2:7][CH:4]([CH:5]=[CH:6]1)[CH2:3][CH:2]2[NH:8][C:9](=[S:10])[NH:11][N:12]=[CH:18][C:14]1[NH:13][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 13854Pyrrole-2-carboxaldehydeHCID 2740681N1-bicyclo[2.2.1]hept-5-en-2-ylhydrazine-1-carbothioamide

Product 1

HCID 136360280HCID 136360280, compound

Procedure

The title compound was prepared from a mixture of N1-bicyclo[2.2.1]hept-5-en-2-ylhydrazine-1-carbothioamide (100 mg, 0.56 mmol) and pyrrole-2-carboxaldehyde (53 mg, 0.56 mmol) similar to Example 3 and isolated as a yellow oil (3 mg, 2%). 1H NMR (CDCl3): 9.28 (s, 1H), 8.99 (s, 1H), 7.68 (s, 1H), 7.22 (d, J=7.8 Hz, 1H), 6.94 (s, 1H), 6.53-6.51 (m, 1H), 6.29-6.26 (m, 1H), 6.22-6.13 (m, 2H), 4.30-4.24 (m, 1H), 3.04 (s, 1H), 2.94 (s, 1H), 1.92-1.84 (m, 1H), 1.65 (d, J=9.0 Hz, 1H), 1.50 (d, J=9.0 Hz, 1H), 1.45-1.38 (m, 1H).

Sources & evidence

ORD record
ord-443e503301d249eb936c047fab50edd6
Source dataset
uspto-grants-2004_09
Patent number
US06794400B2

Reaction notes

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