2-Acetylthiazole → HCID 85049365, compound

HRID 1007274Notes

Reaction equation

HRID 1007274 reaction equation
[CH:1]12[CH2:7][CH:4]([CH:5]=[CH:6]1)[CH2:3][CH:2]2[NH:8][C:9]([NH:11][NH2:12])=[S:10].[C:13]([C:16]1[S:17][CH:18]=[CH:19][N:20]=1)(=O)[CH3:14]>>[CH:1]12[CH2:7][CH:4]([CH:5]=[CH:6]1)[CH2:3][CH:2]2[NH:8][C:9](=[S:10])[NH:11][N:12]=[CH:14][CH2:13][C:16]1[S:17][CH:18]=[CH:19][N:20]=1

Participants

3

Reactant 2

HCID 5201082-AcetylthiazoleHCID 2740681N1-bicyclo[2.2.1]hept-5-en-2-ylhydrazine-1-carbothioamide

Product 1

HCID 85049365HCID 85049365, compound

Procedure

The title compound was prepared from a mixture of N1-bicyclo[2.2.1]hept-5-en-2-ylhydrazine-1-carbothioamide (50 mg, 0.273 mmol) and 2-acetylthiazole (41 mg, 0.33 mmol) similar to Example 3 and isolated as an off-white solid (30 mg, 37%). 1H NMR (DMSO-d6): 9.98 (s, 1H), 9.62 (s, 1H), 7.89 (m, 2H), 7.77 (m, 1H), 6.16 (ddd, J=8.1, 5.1, 2.7 Hz, 2H), 4.23 (m, 1H), 3.04 (s, 2H), 2.23 (s, 3H), 1.87-1.50 (m, 4H).

Sources & evidence

ORD record
ord-95a21ec9b8c14d3f82e35f7ea327b368
Source dataset
uspto-grants-2004_09
Patent number
US06794400B2

Reaction notes

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